Thromboplastin reference preparations.

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A comparison of brain thromboplastin preparations used for testing prothrombin efficiency.

Methods 1. Quick's Method.-The method in use in this laboratory has been basically that of Quick, StanleyBrown, and Bancroft (1935), as modified later by Quick himself and others (Biggs and Macfarlane, 1949). In this method a fresh saline emulsion is prepared daily from a stock of acetone-dried human brain powder, which is kept stored in a vacuum desiccator at 40 C. 2. Toohey's Method.-This met...

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The effect of different nitrate preparations on plasma heparin concentrations and the activated partial thromboplastin time.

There is evidence that intravenous nitrates which are frequently used in acute coronary syndromes may interfere with the anticoagulant effect of heparin. We compared the effect of two different nitrate preparations on the activated partial thromboplastin time (APTT), anti-thrombin III activity (AT III) and plasma heparin levels in patients (n = 50) undergoing routine percutaneous transluminal c...

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Standardisation of the one-stage prothrombin time test for the control of anticoagulant therapy. The availability and use of thromboplastin reference preparations.

3 Thomford, N. R., Woolner, L. B., and Clagett, 0. T.,J5ournal of Thoracic and Cardiovascular Surgery, 1965, 49, 357. 4 Effler, D. B., and Blades, B., J7ournal of Thoracic and Cardiovascular Surgery, 1948, 17, 27. 5 Hood, R. T., jun., McBurney, R. P., and Clagett, 0. T., J'ournal of Thoracic and Cardiovascular Surgery, 1955, 30, 81. 6 Ehrenhaft, J. L., Lawrence, M. S., and Sensenig, D. M., Arch...

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European Concerted Action on Anticoagulation. A multicentre calibration study of WHO international reference preparations for thromboplastin, rabbit (RBT/90) and human (rTF/95).

A 10 centre calibration was performed after six years to determine the international sensitivity index (ISI) of rTF/95 relative to RBT/90, and to assess any international normalised ratio (INR) bias compared with the original multicentre calibration. After exclusion of one outlying centre, the follow up calibration gave a mean ISI for rTF/95 of 0.99, which although a small difference, is signif...

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Effect of the choice of WHO International Reference Preparation for thromboplastin on International Normalised Ratios.

AIMS To compare the International Normalised Ratio (INR) obtained directly with the two types of WHO plain International Reference Preparation for thromboplastin in patients treated with coumarin. METHODS Prothrombin times were performed in parallel at four centres using WHO human plain IRP (BCT/253) and rabbit plain IRP (RBT/79). Sixty patients and 20 normal controls were tested at each cent...

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ژورنال

عنوان ژورنال: BMJ

سال: 1971

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.3.5775.638-c